Phonatory impairment in Parkinson's disease: Evidence from nonlinear dynamic analysis and perturbation analysis
Phonatory impairment in Parkinson's disease: Evidence from nonlinear dynamic analysis and perturbation analysis
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DOI：
10.1016/j.jvoice.2005.08.011
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发表时间：
2007-01-01
期刊：
影响因子：
2.2
通讯作者：
Zhang, Yu
中科院分区：
文献类型：
--
作者：
Rahn, Douglas A., III;Chou, Maggie;Zhang, Yu
许多帕金森病（PD）患者最终会随着病情的发展而出现声音障碍。使用标准的扰动分析（如抖动和微光等参数）来测量发声信号的波动可能会抑制研究人员识别严重紊乱的模式，这些模式似乎存在于一些PD患者的声音中。非线性动态分析可以量化这些非周期性的模式，这表明严重的病理，通常是由嘶哑的感知特征。在这里，持续元音发音的一个异质组的PD受试者（20名女性和21名男性）进行了比较，与对照组（22名女性和18名男性）的非线性动态分析（D-2）和扰动分析的结果。结果显示，PD受试者作为一个整体，有显着较高的D-2值比对照组（P = 0.016），这表明增加信号的复杂性PD声乐病理。这两组的比较差异在抖动方面具有显著性（P = 0.014），但在闪烁方面无显著性（P = 0.695）。此外，这三项指标的表现受受试者性别的影响。非线性动力学分析显示，女性PD组的D-2显著高于女性对照组（P = 0.001），但抖动和闪烁没有显示出这种差异。男性PD组的抖动在统计学上高于男性对照组（P = 0.036），但这些组在D2或微光方面没有差异。总之，非线性动力学分析可能是一种有价值的方法，用于诊断帕金森病喉病理。
Many persons with Parkinson's disease (PD) will eventually experience vocal impairment as their condition advances. Using standard perturbation analyses (parameters like jitter and shimmer) to measure fluctuations in phonatory signal may inhibit researchers from recognizing severely disordered patterns that seem to be present in the voices of some PD patients. Nonlinear dynamic analysis can quantify these aperiodic patterns, which indicate severe pathology that is usually characterized perceptually by hoarseness. Here, sustained vowel phonations of a heterogeneous group of PD subjects (20 women and 21 men) were compared with those of a control group (22 women and 18 men) based on results of nonlinear dynamic analyses (D-2) and perturbation analyses. Results showed PD subjects as a whole to have significantly higher D-2 values than control subjects (P = 0.016), which indicates increased signal complexity in PD vocal pathology. Differences in the comparison of these two groups were significant in jitter (P = 0.014) but nonsignificant in shimmer (P = 0.695). Furthermore, the performance on these three measures was affected by subject sex. Nonlinear dynamic analysis showed significantly higher D-2 in the female PD group than in the female control group (P = 0.001), but jitter and shimmer did not show such a difference. The male PD group had statistically higher jitter than the male control group (P = 0.036), but these groups did not differ in D2 or shimmer. Overall, nonlinear dynamic analysis may be a valuable method for the diagnosis of Parkinsonian laryngeal pathology.