HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa
HIV Target Cells in Schistosoma haematobium-Infected Female Genital Mucosa
复制标题
DOI：
10.4269/ajtmh.2011.11-0135
复制
发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Kjetland, Eyrun Floerecke
中科院分区：
文献类型：
--
作者：
Jourdan, Peter Mark;Holmen, Sigve Dhondup;Kjetland, Eyrun Floerecke
寄生虫埃及血吸虫经常引起妇女生殖器病变，并可能增加人类免疫缺陷病毒（艾滋病毒）传播的风险。这项研究定量的HIV靶细胞在受感染的女性生殖器粘膜。对有和无血吸虫病的宫颈阴道活检进行免疫染色，以定量CD4（+）T淋巴细胞（CD3，CD8），巨噬细胞（CD68）和树突状朗格汉斯细胞（S100蛋白）。我们发现，与无卵细胞的宫颈阴道粘膜相比，卵细胞周围的生殖器粘膜CD4（+）T淋巴细胞和巨噬细胞的密度显著更高（分别为P = 0.034和P = 0.018）。我们发现朗格汉斯细胞密度没有增加（P = 0.25）。本研究表明S.埃及血蜱可能会显着增加女性生殖器中HIV靶细胞（CD 4（+）T淋巴细胞和巨噬细胞）的密度，为HIV传播创造有利的环境。需要进一步的研究来证实这些发现，并评估抗精子治疗对女性生殖器血吸虫病的影响。
The parasite Schistosoma haematobium frequently causes genital lesions in women and could increase the risk of human immunodeficiency virus (HIV) transmission. This study quantifies the HIV target cells in schistosome-infected female genital mucosa. Cervicovaginal biopsies with and without schistosomiasis were immunostained for quantification of CD4(+) T lymphocytes (CD3, CD8), macrophages (CD68), and dendritic Langerhans cells (S100 protein). We found significantly higher densities of genital mucosal CD4(+) T lymphocytes and macrophages surrounding schistosome ova compared with cervicovaginal mucosa without ova (P = 0.034 and P = 0.018, respectively). We found no increased density of Langerhans cells (P = 0.25). This study indicates that S. haematobium may significantly increase the density of HIV target cells (CD4(+) T lymphocytes and macrophages) in the female genitals, creating a beneficial setting for HIV transmission. Further studies are needed to confirm these findings and to evaluate the effect of anti-schistosomal treatment on female genital schistosomiasis.