Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study
Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study
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DOI：
10.1016/j.jstrokecerebrovasdis.2023.106998
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发表时间：
2023-02-11
影响因子：
2.5
通讯作者：
Deng，Shumin
中科院分区：
文献类型：
--
作者：
Wang，Yuye;Qiu，Luying;Deng，Shumin
目的Let-7家族成员是缺血性脑卒中发病机制中的重要调节分子。我们预测let-7家族启动子的遗传变异可能与缺血性中风的风险有关。本研究探讨let-7家族启动子中rs 10877887和rs 13293512与缺血性脑卒中易感性的关系，收集914例缺血性脑卒中患者和836例对照者的临床资料和外周血标本。所有的统计分析进行了使用SPSS.ResultsOur分析结果显示，rs 10877887 TC+CC基因型在显性模型与缺血性中风的风险较低，比TT基因型。在rs 13293512分析中，男性人群中具有杂合TC或纯合CC基因型的个体比具有野生TT基因型的个体显示出更高的缺血性卒中几率。rs 10877887 C等位基因与rs 13293512 T等位基因之间存在倍增交互作用。在rs 13293512 T等位基因的存在下，rs 10877887 C等位基因对缺血性卒中风险的影响增加。类似地，在rs 10877887 C等位基因存在的情况下，rs 13293512 T等位基因对缺血性卒中风险的结果升高。此外，rs 13293512 CC基因型似乎导致缺血性stroke.ConclusionOur研究结果表明，这两个SNP可能有一个共同的作用，IS和可能作为潜在的风险标记。检测let-7启动子多态性可以提高对IS风险的认识，这指导具有风险等位基因的个体以适当的频率进行定期检查，以避免发生疾病。
PurposeLet-7 family members serve as crucial regulatory molecules in the pathogenesis of ischemic stroke. We predicted that genetic variations in the let-7 family's promoters may be linked to the risk of ischemic stroke. The connection of rs10877887 and rs13293512 in the let-7 family promoters with liability to ischemic stroke was explored in this study.Patients and methodsClinical data and peripheral blood samples were collected from 914 ischemic stroke patients and 836 controls in this case–control study. All statistical analyses were carried out using SPSS.ResultsOur analysis results reveal that the rs10877887 TC+CC genotype in the dominant model is associated with a lower risk of ischemic stroke than the TT genotype. Individuals with heterozygous TC or homozygous CC genotypes in the male population showed higher odds of ischemic stroke than those with the wild TT genotype in rs13293512 analysis. Furthermore, there existed a multiplicative interaction between the rs10877887 C allele and the rs13293512 T allele. In the presence of the rs13293512 T allele, the effect of the rs10877887 C allele on ischemic stroke risk was increased. Similarly, in the presence of the rs10877887 C allele, the outcome of the rs13293512 T allele on ischemic stroke risk was elevated. In addition, the rs13293512 CC genotype seemed to lead to an earlier onset of ischemic stroke.ConclusionOur findings indicated that these two SNPs might have a joint role in IS and could potentially act as risk markers. Detecting let-7 promoter polymorphisms could raise awareness of the risk of IS, which directed individuals with risk alleles to have regular checks at an appropriate frequency to avoid developing the disease.