The rhamnose pathway
The rhamnose pathway
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DOI：
10.1016/s0959-440x(00)00145-7
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发表时间：
2000-12-01
影响因子：
6.8
通讯作者：
Naismith, JH
中科院分区：
文献类型：
--
作者：
Giraud, MF;Naismith, JH
l -鼠李糖是一种广泛存在于细菌和植物中的脱氧糖。有关它在许多致病菌中起重要作用的证据不断出现。参与其生物合成途径的四种酶中有两种的晶体结构已被报道，另外两种已提交发表。这种途径在人类中并不存在，这使得这种途径的酶成为非常有吸引力的治疗干预目标。
L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.