Mechanisms of disease: Fuchs' endothelial dystrophy.
Mechanisms of disease: Fuchs' endothelial dystrophy.
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DOI：
10.1016/s0896-1549(01)00016-5
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发表时间：
2002-03-01
期刊：
影响因子：
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通讯作者：
Colby, Kathryn
中科院分区：
文献类型：
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作者：
Borboli, Sheila;Colby, Kathryn
Fuchs'内皮营养不良是一种常见的疾病，自Ernst Fuchs于1910年首次报道以来一直被广泛研究。虽然其临床过程和病理特征被很好地描述，病因和遗传方式仍然是不明确的。正在进行的工作是评估线粒体DNA在FED发病机制中的作用。FED的手术治疗取得了重大进展，部分利用了屈光手术的一些技术，到目前为止是有希望的。需要更大的病例系列来充分评估这些技术的安全性、有效性和适应症。事实上，现在正是“重新审视衰老疾病”的时候[9]。
Fuchs' endothelial dystrophy is a common disease that has been widely studied since its initial report in 1910 by Ernst Fuchs. Although its clinical course and pathologic characteristics are well described, the etiology and inheritance pattern are still ambiguous. Ongoing work is evaluating the role of mitochondrial DNA in the pathogenesis of FED. Significant advances in the surgical treatment of FED, in part utilizing some of the techniques of refractive surgery, are promising thus far. Larger case series are needed to fully assess the safety, efficacy and indications of these techniques. Indeed, the time is right to take "a fresh look at an aging disease" [9].