The effect of ovariectomy on the temporomandibular joints of growing rats
The effect of ovariectomy on the temporomandibular joints of growing rats
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DOI：
10.1016/s0278-2391(96)90352-3
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发表时间：
1996-10-01
影响因子：
1.9
通讯作者：
Oka, N
中科院分区：
文献类型：
--
作者：
Okuda, T;Yasuoka, T;Oka, N
目的：本研究旨在探讨卵巢切除对幼年大鼠颞下颌关节（TMJ）的影响。材料与方法：4周龄雌性Wistar大鼠，切除卵巢后，分别于术后1、2、4、8周处死。颞下颌关节的组织形态计量学研究，以同步的方式与年龄匹配的假手术对照组。结果：假手术对照组血清雌激素、降钙素水平随年龄增长而升高，血清降钙素水平随年龄增长而升高。在12周时观察到骨体积增加，同时类骨质表面增加。关节软组织厚度随年龄增长而减小。在卵巢切除动物中，在实验期间未检测到血清雌激素。观察到甲状旁腺激素水平的双相变化，在卵巢切除术后1周和2周降低，在术后4周和8周升高，而降钙素水平观察到恒定值。在卵巢切除术后1周、2周和4周，髁突前部和中部的关节软组织厚度增加，而在后部没有观察到明显的变化，在实验期间骨体积减少，特别是在后部。在前区的骨赘也观察到8周postoperatives.Conclusions：雌激素缺乏症大鼠在青春期容易通过改变血清降钙素和甲状旁腺激素水平的TMJ的改变。
Purpose: This investigation studied the effects of ovariectomy, on the temporomandibular joints (TMJ) of young rats.Materials and Methods: four-week-old female Wistar rats were ovariectomized and killed at the intervals of 1, 2, 4, and 8 weeks postoperatively. Histomorphometric study of the TMJ was performed in a synchronous manner with an age-matched sham-operated control group. The serum levels of estrogen, calcitonin, and C-terminus parathyroid hormone were also determined.Results: In the sham-operated control group, the serum levels of estrogen and calcitonin increased with age. An increase of the bone volume, with a concomitant increase of the osteoid surface, was observed at 12 weeks. Thickness of the articular soft tissue was decreased with increasing age. In the ovariectomized animals, serum estrogen was not detected during the experiment. A biphasic change in the parathyroid hormone level, with decreases at 1 and 2 weeks after the ovariectomy and increases at 4 and 8 weeks postoperatively, was observed, whereas a constant value was noted in the calcitonin level, Thickness of the articular soft tissue was increased in the anterior and central portions of the condyle at 1, 2, and 4 weeks after the ovariectomy, whereas no appreciable changes were observed in the posterior portion, The bone volume was decreased during the experiment, particularly in the posterior portion. An osteophyte in the anterior region was also observed 8 weeks postoperatively.Conclusions: Estrogen deficiency in rats during puberty predisposes to alterations of the TMJ through changes in serum calcitonin and parathyroid hormone levels.