Axon and neuron numbers after forelimb amputation in neonatal rats.
Axon and neuron numbers after forelimb amputation in neonatal rats.
复制标题
新生大鼠前肢截肢后轴突和神经元数量。
DOI：
10.1016/0014-4886(86)90136-6
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发表时间：
1986
影响因子：
5.3
通讯作者：
Hulsebosch,CE
中科院分区：
文献类型：
--
作者：
Heath2nd,DD;Coggeshall,RE;Hulsebosch,CE
与成年哺乳动物相比，新生儿周围神经损伤后初级感觉神经元丢失更多，但恢复更好，这似乎是一个悖论。一种可能的解释是，存活的神经元在新生儿中萌发。为了验证这一点，对新生大鼠的前肢进行了截肢，导致许多初级感觉神经元死亡。测定健侧和截肢侧背根神经节的神经元数目，背根和腹根有髓纤维和无髓纤维的数目。截肢侧神经节胞体丢失30%，背根纤维减少16%，腹根纤维增加20%。这些数据与轴突分支或从存活的感觉神经元发芽的假设是一致的。此外，形态计量学分析显示，远端突起被切断的感觉细胞的中央突起的髓鞘-轴突关系发生了变化。
It seems a paradox that more primary sensory neurons are lost but recovery is better after peripheral nerve injury in neonates as compared to adult mammals. A possible explanation is that surviving neurons sprout in the neonate. To test this, forelimbs in neonatal rats were amputated, which caused the death of many primary sensory neurons. The number of neurons in the dorsal root ganglia, and the number of myelinated and unmyelinated fibers in the dorsal and ventral roots were determined on the amputated and contralateral normal sides. On the amputated side, soma loss in the ganglia was 30%, and the fiber numbers were decreased by 16% in the dorsal root and increased by 20% in the ventral root. These data are compatible with the hypothesis that there is axonal branching or sprouting from surviving sensory neurons. In addition, morphometric analyses showed a changed myelin-axon relationship for central processes of sensory cells whose distal processes have been cut.