Chemistry of carcinogenic metals.
Chemistry of carcinogenic metals.
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DOI：
10.1289/ehp.8140207
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发表时间：
1981-08
影响因子：
10.4
通讯作者：
Martell AE
中科院分区：
文献类型：
--
作者：
Martell AE
描述了已知和疑似致癌金属离子的周期性分布，并根据硬和软酸碱的一般理论解释了各种类型金属离子的化学行为。阐明了螯合作用，并讨论了金属螯合物在非常稀的溶液中的相对较高的稳定性。螯合效应的概念被扩展到解释大环和穴状配合物的高稳定性。使用平衡数据来确定不同的溶液条件下的金属离子和配合物的形态的程序进行说明。氢离子，竞争金属离子，水解和沉淀的干扰进行评估的方法进行了解释，并适用于系统中含有铁（III）螯合物的14螯合剂设计的有效结合的铁离子。可用于建立的多齿配体的供体基团，并在其中它们可以结合起来，以实现高亲和力和选择性的某些类型的金属离子的方式进行了解释。
The periodic distribution of known and suspected carcinogenic metal ions is described, and the chemical behavior of various types of metal ions is explained in terms of the general theory of hard and soft acids and bases. The chelate effect is elucidated, and the relatively high stability of metal chelates in very dilute solutions is discussed. The concepts employed for the chelate effect are extended to explain the high stabilities of macrocyclic and cryptate complexes. Procedures for the use of equilibrium data to determine the speciation of metal ions and complexes under varying solution conditions are described. Methods for assessing the interferences by hydrogen ion, competing metal ions, hydrolysis, and precipitation are explained, and are applied to systems containing iron(III) chelates of fourteen chelating agents designed for effective binding of the ferric ion. The donor groups available for the building up of multidentate ligands are presented, and the ways in which they may be combined to achieve high affinity and selectivity for certain types of metal ions are explained.