Adherence to a Mediterranean diet and survival in a Greek population
Adherence to a Mediterranean diet and survival in a Greek population
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DOI：
10.1056/nejmoa025039
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发表时间：
2003-06-26
影响因子：
158.5
通讯作者：
Trichopoulos, D
中科院分区：
文献类型：
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作者：
Trichopoulou, A;Costacou, T;Trichopoulos, D
背景：坚持地中海式饮食可以提高寿命，但相关数据是limited.METHODS：我们进行了一项基于人群的前瞻性调查，涉及22,043名希腊成年人，他们完成了一项广泛的、有效的、食物频率基线调查问卷。传统地中海饮食的依从性通过10分地中海饮食量表进行评估，该量表包含该饮食的显著特征（评分范围为0至9，分数越高表示依从性越强）。我们使用比例风险回归来评估坚持地中海饮食和总死亡率之间的关系，以及由于冠心病和癌症的死亡率，调整年龄，性别，体重指数，体力活动水平，和其他潜在的混杂因素。更高程度的坚持地中海饮食与总死亡率的降低相关（调整后的死亡风险比与地中海饮食评分增加两点相关，0.75 [95%置信区间，0.64至0.87]）。对于冠心病死亡（调整后的风险比，0.67 [95%置信区间，0.47 ~ 0.94]）和癌症死亡（调整后的风险比，0.76 [95%置信区间，0.59 ~ 0.98]），更大程度地坚持这种饮食与死亡呈明显的负相关。个别食物组之间的协会有助于地中海饮食评分和总mortality were generally not significant.CONCLUSIONS：更大的坚持传统的地中海饮食与总死亡率显着降低。
BACKGROUND:Adherence to a Mediterranean diet may improve longevity, but relevant data are limited.METHODS:We conducted a population-based, prospective investigation involving 22,043 adults in Greece who completed an extensive, validated, food-frequency questionnaire at base line. Adherence to the traditional Mediterranean diet was assessed by a 10-point Mediterranean-diet scale that incorporated the salient characteristics of this diet (range of scores, 0 to 9, with higher scores indicating greater adherence). We used proportional-hazards regression to assess the relation between adherence to the Mediterranean diet and total mortality, as well as mortality due to coronary heart disease and mortality due to cancer, with adjustment for age, sex, body-mass index, physical-activity level, and other potential confounders.RESULTS:During a median of 44 months of follow-up, there were 275 deaths. A higher degree of adherence to the Mediterranean diet was associated with a reduction in total mortality (adjusted hazard ratio for death associated with a two-point increment in the Mediterranean-diet score, 0.75 [95 percent confidence interval, 0.64 to 0.87]). An inverse association with greater adherence to this diet was evident for both death due to coronary heart disease (adjusted hazard ratio, 0.67 [95 percent confidence interval, 0.47 to 0.94]) and death due to cancer (adjusted hazard ratio, 0.76 [95 percent confidence interval, 0.59 to 0.98]). Associations between individual food groups contributing to the Mediterranean-diet score and total mortality were generally not significant.CONCLUSIONS:Greater adherence to the traditional Mediterranean diet is associated with a significant reduction in total mortality.