Inhibition of melanoma metastases by fenofibrate
Inhibition of melanoma metastases by fenofibrate
复制标题
DOI：
10.1007/s00403-004-0479-y
复制
发表时间：
2004-04-01
影响因子：
3
通讯作者：
Slominski, A
中科院分区：
文献类型：
--
作者：
Grabacka, M;Placha, W;Slominski, A
过氧化物酶体增殖物激活受体（PPAR）α的配体非诺贝特对Bomirski仓鼠黑色素瘤s.c.生长和转移潜力的影响肿瘤，色素线（BHM Ma）进行了体内研究。RT-PCR和Western-blot分析显示BHM Ma细胞中存在PPAR α的mRNA和蛋白。与对照组相比，经口给予非诺贝特的动物在肺中形成的转移灶显著较少;然而，原发性肿瘤生长保持不变。这一观察结果对于非诺贝特在黑色素瘤化学预防中的潜在用途是有趣的。
The effect of fenofibrate, a ligand of peroxisome proliferator-activated receptor (PPAR) alpha, on the growth and metastatic potential of Bomirski hamster melanoma s.c. tumors, pigmented line (BHM Ma) was investigated in vivo. RT-PCR and Western-blot analyses revealed the presence of mRNA and protein of PPAR alpha in BHM Ma cells. The animals treated orally with fenofibrate developed significantly fewer metastatic foci in the lungs, as compared to the control group; however, primary tumor growth remained unaltered. This observation is interesting in respect of the potential use of fenofibrate in melanoma chemoprevention.