Pain Catastrophizing and EEG-α Asymmetry.
Pain Catastrophizing and EEG-α Asymmetry.
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DOI：
10.1097/ajp.0000000000000182
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Howe JD
中科院分区：
文献类型：
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作者：
Jensen MP;Gianas A;Sherlin LH;Howe JD
疼痛灾难化被认为在慢性疼痛的发展和维持及其对功能的负面影响中发挥因果作用。然而，很少有研究探讨的因素，可能有助于发展和维持的灾难。前部不对称性和情绪（AAE）模型假设，左前脑区域的更多活动与参与接近反应的倾向有关（通常但不总是与正效价相关），而更多的右前脑活动与参与更多退缩反应的倾向有关（通常与负效价相关）。鉴于灾难化与（1）接近与回避疼痛应对方式和（2）对疼痛的情感反应之间存在一致的关联，AAE模型将预测更多的左（右）前脑活动将前瞻性地预测未来的灾难化。采用30例脊髓损伤患者的脑电图数据计算的前部不对称测量值与EEG记录后两年内获得的灾难性评分相关。与AAE模型一致，反映左前活动大于右前活动的前不对称评分与随后的灾难化呈负相关。研究发现确定了一个生物因素，可能与更大的脆弱性疼痛相关的灾难。如果在未来的研究中重复，这些发现为治疗灾难化提供了新的可能性，这可能有助于改善疼痛治疗结果。
Pain catastrophizing is thought to play a causal role in the development and maintenance of chronic pain and its negative impact on functioning. However, few studies have examined the factors that might contribute to the development and maintenance of catastrophizing. The anterior asymmetry and emotion (AAE) model hypothesizes that more activity in left anterior brain regions is associated with a tendency to engage in approach responses (often, but not always, associated with positive valance), and that more right anterior activity is associated with a tendency to engage in more withdrawal responses (often associated with negative valance). Given the consistent associations found between catastrophizing and both (1) approach vs avoidance pain coping styles and (2) affective responses to pain, the AAE model would predict that more left (versus right) anterior brain activity would prospectively predict future catastrophizing. Anterior asymmetry measures computed using electroencephalogram data from 30 individuals with spinal cord injury were correlated with catastrophizing scores obtained two years after the EEG recording. Consistent with the AAE model, anterior asymmetry scores reflecting greater left than right anterior activity were negatively associated with subsequent catastrophizing. The study findings identify a biological factor that may be associated with greater vulnerability to pain-related catastrophizing. If replicated in future research, the findings suggest new possibilities for treating catastrophizing, which may then contribute to improved pain treatment outcomes.