Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells
Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells
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DOI：
10.1046/j.1365-2249.1996.d01-842.x
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发表时间：
1996-11-01
影响因子：
4.6
通讯作者：
Tamaki, K
中科院分区：
文献类型：
--
作者：
Kanda, N;Tsuchida, T;Tamaki, K
我们在体外研究了睾酮对人外周血单个核细胞（PBMC）自发产生免疫球蛋白的影响。替吉奥抑制IgG和IgM的生产由PBMC从男性和女性。睾酮的抑制作用在大于1 nM的剂量下显示，呈剂量依赖性增加，并在100 nM时达到平台。剂量
We studied the in vitro effect of testosterone on spontaneous immunoglobulin production by human peripheral blood mononuclear cells (PBMC). Testosterone inhibited IgG and IgM production by PBMC both from males and females. The inhibitory effect of testosterone was revealed at doses more than 1 nM, increased dose-dependently, and reached a plateau at 100 nM. At doses