Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.
Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.
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DOI：
10.1038/ng.2919
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发表时间：
2014-04
期刊：
影响因子：
30.8
通讯作者：
O'Farrell, Patrick H.
中科院分区：
文献类型：
--
作者：
Ma, Hansong;Xu, Hong;O'Farrell, Patrick H.
It is not known how selection affects mutations on the multicopied mitochondrial genome . We transferred cytoplasm between D. melanogaster embryos carrying mitochondrial mutations to create heteroplasmic lines transmitting two mitochondrial genotypes. Increased temperature imposed selection against a temperature sensitive mutation in cytochrome oxidase, driving declines in the abundance of the mutant genome over successive generations. Selection did not influence the health or fertility of the flies, but acted during mid oogenesis to influence competition between the genomes. While mitochondria might incur an advantage by selective localization, survival or proliferation, timing and insensitivity to parkin mutation suggest that preferential proliferation underlies selection. Selection drove complete replacement of the temperature sensitive mitochondrial genome by a wild type genome, but selection also stabilized multigenerational transmission of two genomes carrying complementing detrimental mutations. While so balanced, stably transmitted detrimental mutations have no phenotype but their segregation could contribute to disease phenotypes and somatic aging.
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