Clinical presentation of the "depression-executive dysfunction syndrome" of late life.
Clinical presentation of the "depression-executive dysfunction syndrome" of late life.
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DOI：
10.1097/00019442-200201000-00012
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
G. Alexopoulos;D. Kiosses;S. Klimstra;B. Kalayam;M. Bruce
中科院分区：
文献类型：
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作者：
G. Alexopoulos;D. Kiosses;S. Klimstra;B. Kalayam;M. Bruce
有人提出，“抑郁-执行功能障碍（DED）综合征”发生在晚年。这一论断是基于临床，神经病理学和神经影像学研究结果表明，额纹状体功能障碍有助于抑郁症和执行功能障碍的发展，并影响抑郁症的过程。作者描述了DED的临床表现及其与残疾的关系，研究了126名患有重度抑郁症的老年受试者，并评估了抑郁症状、认知功能、残疾和人格维度。DED综合征患者的语言流畅性降低，视觉命名受损，偏执，对活动失去兴趣，精神发育迟滞，但表现出相当轻微的植物人综合征。抑郁性痴呆，特别是精神发育迟滞和对活动失去兴趣，导致DED患者残疾，而偏执与独立于执行功能障碍的残疾相关。这些发现可能有助于临床医生识别需要警惕随访的患者，因为发现伴有执行功能障碍的抑郁症与残疾，治疗反应差，复发和复发有关。
It has been proposed that a "depression-executive dysfunction (DED) syndrome" occurs in late life. This assertion was based on clinical, neuropathological, and neuroimaging findings suggesting that frontostriatal dysfunctions contribute to the development of both depression and executive dysfunction and influence the course of depression. The authors describe the clinical presentation of DED and its relationship to disability, studying 126 elderly subjects with major depression and evaluating depressive symptoms, cognitive functioning, disability, and personality dimensions. Patients with the DED syndrome had reduced fluency, impaired visual naming, paranoia, loss of interest in activities, and psychomotor retardation, but showed a rather mild vegetative syndrome. Depressive symptomatology, and especially psychomotor retardation and loss of interest in activities, contributed to disability in DED patients, whereas paranoia was associated with disability independently of executive dysfunction. These findings may aid clinicians in identifying patients needing vigilant follow-up, because depression with executive dysfunction was found to be associated with disability, poor treatment response, relapse, and recurrence.