Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum.
Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum.
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DOI：
10.1111/ejn.13462
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Maidment NT
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文献类型：
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作者：
Ostlund SB;Liu AT;Wassum KM;Maidment NT
背内侧纹状体（DMS）与灵活的、基于结果的决策密切相关，包括结果特异性巴甫洛夫-工具传递效应（PIT），该效应测量奖励预测线索优先激励与预测奖励相关的行动的倾向，而不是与不同奖励相关的行动。虽然这种效应的神经化学基础还不清楚，但越来越多的证据表明纹状体乙酰胆碱信号可能起着重要作用。目前的研究调查了这一假设，通过评估的影响，内DMS输注的烟碱拮抗剂美加明或毒蕈碱拮抗剂东莨菪碱对特定的PIT在大鼠中的表达。这些治疗产生了可分离的行为效应。美加明输注增强大鼠倾向于使用特定的线索引发的结果预期，以选择与预测结果训练的任何动作，相对于它们在载体输注后测试时的表现。与此相反，东莨菪碱输液似乎使工具性能不敏感的奖励配对线索的动机影响。这些药物治疗对条件性食物杯接近行为没有可检测的影响，表明它们选择性地扰乱了线索引导的动作选择，而没有在行为控制中产生更广泛的改变。我们的研究结果揭示了DMS乙酰胆碱信号在调节线索诱发的奖励期望对工具性动作选择的影响中的重要作用。
The dorsomedial striatum (DMS) has been strongly implicated in flexible, outcome-based decision making, including the outcome-specific Pavlovian-to-instrumental transfer effect (PIT), which measures the tendency for a reward-predictive cue to preferentially motivate actions that have been associated with the predicted reward over actions associated with different rewards. Although the neurochemical underpinnings of this effect are not well understood, there is growing evidence that striatal acetylcholine signaling may play an important role. The current study investigated this hypothesis by assessing the effects of intra-DMS infusions of the nicotinic antagonist mecamylamine or the muscarinic antagonist scopolamine on expression of specific PIT in rats. These treatments produced dissociable behavioral effects. Mecamylamine infusions enhanced rats’ tendency to use specific cue-elicited outcome expectations to select whichever action was trained with the predicted outcome, relative to their performance when tested after vehicle infusions. In contrast, scopolamine infusions appeared to render instrumental performance insensitive to this motivational influence of reward-paired cues. These drug treatments had no detectable effect on conditioned food-cup approach behavior, indicating that they selectively perturbed cue-guided action selection without producing more wide-ranging alterations in behavioral control. Our findings reveal an important role for DMS acetylcholine signaling in modulating the impact of cue-evoked reward expectations on instrumental action selection.