Fluorescent nanoparticle sensors with tailor-made recognition units and proximate fluorescent reporter groups
Fluorescent nanoparticle sensors with tailor-made recognition units and proximate fluorescent reporter groups
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DOI：
10.1039/c8nj01139g
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发表时间：
2018-06-21
影响因子：
3.3
通讯作者：
Zhao, Yan
中科院分区：
文献类型：
--
作者：
Xing, Xiaoyu;Zhao, Yan
荧光传感器的分子识别单元是其设计和合成最繁琐的部分，但它是传感器特异性的关键。使用易于合成的模块化模板在交联胶束内进行分子印迹，使我们能够使用附近的荧光探针创建分析物特异性结合位点。这种策略可以直接改变独立于报告单元的识别单元，使传感器可能适用于广泛的分子分析物。
The molecular recognition unit of a fluorescent sensor is its most cumbersome part to design and synthesize, but is key to the specificity of the sensor. Molecular imprinting within cross-linked micelles using easily synthesized modular templates allowed us to create analyte-specific binding sites with a nearby fluorescent probe. This strategy makes it straightforward to vary the recognition unit independent of the reporting unit, making the sensor potentially applicable to a wide range of molecular analytes.