Synthesis and Characterization of Dual Modality (CT/MRI) Core-Shell Microparticles for Embolization Purposes
Synthesis and Characterization of Dual Modality (CT/MRI) Core-Shell Microparticles for Embolization Purposes
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DOI：
10.1021/bm100251s
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发表时间：
2010-06-01
影响因子：
6.2
通讯作者：
Shlomo, Margel
中科院分区：
文献类型：
--
作者：
Hagit, Aviv;Soenke, Bartling;Shlomo, Margel
通过碘化单体2-甲基丙烯酰氧基乙基(2,3,5-三碘苯甲酸酯)MAOETIB与低浓度单体甲基丙烯酸缩水甘油酯GMA的悬浮共聚制备了40-200μm的核P(MAOETIB-GMA)微粒，在颗粒上形成亲水表面。通过在P(MAOETIB-GMA)颗粒的表面上成核氧化铁纳米粒子来涂覆上述核颗粒，制备磁性γ-Fe 2 O 3 /P(MAOETIB-GMA)核壳微粒。随后是氧化铁薄层的逐步生长。这些颗粒的射线不透性和磁性在体外通过 CT 和 MRI 得到证明。这些第一个多模式可见栓塞颗粒的体内栓塞能力在大鼠肾肿瘤栓塞模型中得到了证明。
Core P(MAOETIB-GMA) microparticles of 40-200 mu m were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic gamma-Fe2O3/P(MAOETIB-GMA) core shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model.