Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature
Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature
复制标题
吉兰-巴利综合征的重症监护管理：回顾性结果研究和文献综述
DOI：
10.4103/2348-0548.139106
复制
发表时间：
2014
影响因子：
--
通讯作者：
P. Bithal
中科院分区：
文献类型：
--
作者：
H. Bhagat;H. Dash;R. Chauhan;P. Khanna;P. Bithal
摘要：格林巴利综合征（GBS）是一种免疫介导的疾病，与周围神经系统脱髓鞘和进行性肌无力有关。严重受影响的患者有呼吸功能障碍，可能需要通气支持，这可能导致显着的发病率和死亡率。印度关于严重 GBS 患者预后的数据有限。本研究反映了印度三级医疗机构神经中心对严重 GBS 患者的重症监护管理。材料和方法：本研究旨在回顾性审查入住新德里 AIIMS 神经重症监护病房 (ICU) 的患者记录。记录并分析2000年4月至2005年12月收治的GBS患者的流行病学、临床特征、治疗过程和转归。结果：59 名患者的数据可供纳入研究。入住神经科 ICU 的患者平均年龄为 35 岁，其中男性占多数。通气衰竭是入住 ICU 的最常见指征。 95% 的患者需要平均 30 天的通气支持。死亡数据包括60名患者，其中13名患者在治疗过程中死亡。结论：本研究表明，严重的 GBS 患者可能需要长期机械通气。尽管在专门的神经科 ICU 进行治疗，死亡率仍高达 21%。
Abstract Introduction: Guillain-Barre syndrome (GBS) is an immune mediated disorder which is associated with demyelination of peripheral nervous system and progressive muscle weakness. Severely affected patients have respiratory dysfunction and may need ventilatory support which can cause significant morbidity and mortality. There is limited Indian data with regards to the outcome of severely affected GBS patients. The present study reflects the intensive care management of severely affected GBS patients at neurological centre of a tertiary care institute of India. Materials and Methods: The study was designed to retrospectively review the patient records who were admitted to neurological intensive care unit (ICU) of AIIMS, New Delhi. The epidemiology, clinical features, course of management and outcome of GBS patients admitted between April 2000 to December 2005 were recorded and analysed. Results: The data of 59 patients were available for inclusion in the study. The mean age of patients admitted to neurological ICU was 35 years with male preponderance. Ventilatory failure was the most common indication for ICU admission. 95% patients required ventilatory support for a mean duration of 30 days. The mortality data included 60 patients and 13 patients died during the course of management. Conclusions: The present study indicates that severely affected GBS patients may need prolonged mechanical ventilation. Despite management in a specialized neurological ICU the mortality can be as high as 21%.
影响因子：
3.4
作者：
Miyamoto, K;Oka, N;Akiguchi, I
通讯作者：
Akiguchi, I