Cobalt-Catalyzed Preparation of Arylindium Reagents from Aryl and Heteroaryl Bromides
Cobalt-Catalyzed Preparation of Arylindium Reagents from Aryl and Heteroaryl Bromides
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DOI：
10.1021/jo201174r
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发表时间：
2011-09-16
影响因子：
3.6
通讯作者：
Yoshikai, Naohiko
中科院分区：
文献类型：
--
作者：
Adak, Laksmikanta;Yoshikai, Naohiko
研究了在金属铟和氯化锂存在下，由相应的芳基和杂芳基溴化物直接合成各种芳基试剂的钴邻菲咯啉催化剂。这样形成的芳基试剂在钯的催化下与芳基碘发生高效的交叉偶联反应，可以容忍包括羟基和游离氨基在内的各种官能团。
A cobalt bathophenanthroline catalyst has been developed for the direct preparation of a variety of arylindium reagents from the corresponding aryl and heteroaryl bromides in the presence of indium metal and lithium chloride. The thus-formed arylindium reagents undergo efficient palladium-catalyzed cross-coupling reactions with aryl iodides, tolerating various functional groups including hydroxy and free amino groups.