Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats
Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats
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大黄素和厄贝沙坦对高血压大鼠心室纤维化的影响
DOI：
10.1691/ph.2014.3816
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发表时间：
2014-05-01
期刊：
影响因子：
1.6
通讯作者：
Huang, Dangsheng
中科院分区：
文献类型：
--
作者：
Chen, Qiang;Pang, Lingpin;Huang, Dangsheng
左心室纤维化是高血压最重要的病理生理学结果之一。本研究旨在探讨大黄素及其联合厄贝沙坦对Goldblatt（2K1C）高血压大鼠左室纤维化的影响及其机制。采用两肾一夹（2K1C）法制备Goldblatt高血压大鼠模型，分别给予大黄素、厄贝沙坦或二者联合治疗。收缩压（SBP）、左室重量指数（LVMI）显著升高（P
Left ventricular (LV) fibrosis is one of the most prominent pathophysiological results of hypertension. We initiated this study to investigate the effects and mechanisms of emodin and its combination with irbesartan on LV fibrosis in Goldblatt (2K1C) hypertensive rats. Goldblatt hypertension rats were prepared by two kidney one clip (2K1C) operations and then treated with either emodin, irbesartan or their combination. As a result, the systolic blood pressure (SBP) and the left ventricular mass index (LVMI) increased significantly (P