The emerging role of follistatin under stresses and its implications in diseases.
The emerging role of follistatin under stresses and its implications in diseases.
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卵泡抑素在压力下的新作用及其对疾病的影响。
DOI：
10.1016/j.gene.2017.10.017
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Gao Xiangwei
中科院分区：
文献类型：
--
作者：
Zhang Lingda;Liu Kangli;Han Bing;Xu Zhengping;Gao Xiangwei
卵泡抑素（FST）是一种单链糖基化蛋白，在多种组织中表达。FST的基本生物学功能是结合和中和转化生长因子β（transforming growth factor β，TGF-β）超家族，包括激活素、肌肉生长抑制素和骨形态发生蛋白（bone morphogenetic protein，BMP）。新的证据表明，FST也是一种应激反应蛋白，在各种应激下起保护作用。在大多数情况下，FST通过中和TGF-β超家族而发挥保护作用。然而，在某些情况下，FST易位到细胞核中，以维持细胞内稳态，而不依赖于其细胞外拮抗活性。本文综述了FST在各种应激下的作用及其临床意义，并讨论了其机制。
Follistatin (FST), a single-chain glycosylated protein, is expressed in various tissues. The essential biological function of FST is binding and neutralizing transforming growth factor β (TGF-β) superfamily, including activin, myostatin, and bone morphogenetic protein (BMP). Emerging evidence indicates that FST also serves as a stress responsive protein, which plays a protective role under a variety of stresses. In most cases, FST performs the protective function through its neutralization of TGF-β superfamily. However, under certain circumstances, FST translocates into the nucleus to maintain cellular homeostasis independent of its extracellular antagonism activity. This review provides integrated insight into the most recent advances in understanding the role of FST under various stresses, and the clinical implications corresponding to these findings and discusses the mechanisms to be further studied.