MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response
MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response
复制标题
DOI：
10.1038/ni1026
复制
发表时间：
2004-02-01
影响因子：
30.5
通讯作者：
Harty, JT
中科院分区：
文献类型：
--
作者：
Hamilton, SE;Porter, BB;Harty, JT
单核细胞增生李斯特氏菌感染产生主要组织相容性复合体（MHC）Ia类限制性和MHC Ib类-（H2-M3）限制性效应细胞和记忆CD8（+）T细胞。然而，只有 MHC Ia 类限制性记忆细胞在再次攻击后会扩增，并且尚不清楚通过疫苗接种产生的 MHC Ib 类限制性记忆 CD8(+) T 细胞是否具有保护性。我们在此表明，H2-M3 限制的记忆 CD8(+) T 细胞能够二次扩增，但与原代 H2-M3 限制的效应细胞相反，无法提供保护性免疫。在LM免疫小鼠中，MHC Ia类限制性记忆CD8+T细胞通过限制树突状细胞抗原呈递来阻止H2-M3限制性记忆T细胞群的扩张。因此，H2-M3限制性T细胞的保护性免疫仅限于初次感染，表明记忆MHC Ia类限制性T细胞在继发性感染期间防止非必需的免疫反应。
Listeria monocytogenes infection generates major histocompatibility complex (MHC) class Ia-restricted and MHC class Ib-(H2- M3)-restricted effector and memory CD8(+) T cells. However, only MHC class Ia-restricted memory cells expand after rechallenge, and it is unknown if MHC class Ib-restricted memory CD8(+) T cells generated by vaccination are protective. We show here that H2- M3-restricted memory CD8(+) T cells were capable of secondary expansion but, in contrast to primary H2-M3-restricted effector cells, failed to provide protective immunity. In LM-immune mice, MHC class Ia- restricted memory CD8(+) T cells prevented the expansion of H2-M3-restricted memory T cell populations by limiting dendritic cell antigen presentation. Thus, protective immunity by H2-M3-resricted T cells is limited to primary infection, indicating that memory MHC class Ia- restricted T cells prevent nonessential immune responses during secondary infection.