Is it possible to use autologous adipose graft for wound repair in patients with coagulation disorders?
Is it possible to use autologous adipose graft for wound repair in patients with coagulation disorders?
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DOI：
10.1111/hae.12804
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发表时间：
2016-03-01
期刊：
影响因子：
3.9
通讯作者：
Neme, D.
中科院分区：
文献类型：
--
作者：
Caviglia, H.;Landro, M. E.;Neme, D.
简介：伤口愈合是一个复杂的过程，皮肤在受伤后根据特定的顺序进行修复：止血、炎症、增殖和重塑。细胞疗法具有改善伤口愈合条件的潜力，可应用于急慢性伤口。正常的愈合需要充分的止血功能。凝血障碍患者的止血功能发生改变，可能不会自然愈合。目的：本研究的目的是展示一种简单、安全、廉价的微创技术，用于凝血障碍患者的创面修复。患者和方法：6名患者在阿根廷布宜诺斯艾利斯的血友病基金会参加了这项研究。5名患者患有严重的A型血友病，1名患者患有严重的von Willebrand病。平均年龄37.5岁。1名患者有可伸缩的疤痕(RS)，5名患者有皮瘘(CF)。采用负压吸引法从腹部皮下组织中获取自体脂肪移植物。移植物被离心，脂肪细胞浓缩物被转移到注射器并注射到病变的边缘。结果：每例患者均接受一次脂肪抽吸。6例患者均未发生术中或术后并发症。结论：自体脂肪移植是治疗凝血功能障碍患者复杂创面的一种简单、安全的方法。
Introduction: Wound healing is an intricate process whereby the skin repairs itself after injury according to a specific sequence: haemostasis, inflammation, proliferation and remodelling. Cell therapy has the potential to improve wound healing conditions and can be applied in both acute and chronic wounds. Normal healing requires adequate haemostatic function. Patients with coagulation disorders whose haemostatic function is altered may not heal naturally. Aim: The aim of this study was to show a simple, safe and inexpensive minimally invasive technique for wound repair in patients with coagulation disorders which involves the use of concentrated autologous adipose cells. Patients and method: Six patients were enrolled in this study at the Foundation of Haemophilia, in Buenos Aires, Argentina. Five patients had severe haemophilia type A and one had severe von Willebrand diseases. The average age was 37.5 years old. One patient had a retractile scar (RS) and five patients had cutaneous fistulas (CF). Suction was used to obtain autologous adipose graft from subcutaneous abdominal tissue. The graft was centrifuged and, the adipose cell concentrate was transferred to a syringe and injected in the edge of the lesion. Results: One adipose suction in each patient was performed. There were no intraoperative or postoperative complications in any of the six patients. Conclusions: The application of autologous adipose graft is a simple and safe treatment for complicated wound repair in patients with coagulation disorders.