Vinblastine‐ifosfamide‐cisplatin treatment of bulky seminoma
Vinblastine‐ifosfamide‐cisplatin treatment of bulky seminoma
复制标题
长春花碱-异环磷酰胺-顺铂治疗巨大精原细胞瘤
作者：
C. Clemm;R. Hartenstein;N. Willich;Lothar Boening;W. Wilmanns
Eighteen patients with pure seminoma in advanced Stages IIC‐IV of disease were treated with VIP combination chemotherapy consisting of vinblastine (6 mg/m2, days 1 and 2), ifosfamide (1.5 g/m2, days 1 to 5), and cisplatin (20 mg/m2, days 1 to 5). Eleven patients had Stage IIC, four had Stage III, three had Stage IV, and two had primary extragonadal seminoma. Primary histologic diagnoses were typical seminoma in 15 patients and anaplastic seminoma in three patients. Human chorionic gonadotropin (HCG) levels were elevated to 350 U/1 in eight patients; alpha‐fetoprotein (AFP) levels were always normal. No primary lymphadenectomy was carried out. Seven of 18 patients had prior radiotherapy and were treated because of relapse or progression. There was one early death and one patient has not yet completed therapy. Of 16 evaluable patients, 14 reached complete remission (CR) (88%), which was documented surgically in six cases, whereas in the non‐pretreated group, all nine patients reached CR and in the pretreated group, CR could be induced in five of seven patients (71%). The remission duration ranged from 6+ to 41+ months (median, 29+ months). No relapse has occurred. The bone marrow toxicity of VIP was remarkable. Because of leukopenia below 1000/mm3 and/or thrombopenia below 50,000/mm3, dose reduction and interval prolongation were necessary in 10 of 16 patients, especially in all those who were pretreated. Even though it is not superior to other platin‐based regimens, VIP chemotherapy is highly effective in bulky seminoma with and without prior radiotherapy.
VAB-6作为晚期精原细胞瘤患者的初始治疗。
DOI：
10.1200/jco.1985.3.3.336
发表时间：
1985
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Stanton,GF;Bosl,GJ;WhitmoreJr,WF;Herr,H;Sogani,P;Morse,M;Golbey,RB
通讯作者：
Golbey,RB
顺式二氯二氨铂 (II) 和环磷酰胺联合化疗治疗播散性精原细胞瘤。
DOI：
--
发表时间：
1981
期刊：
Cancer clinical trials
影响因子：
--
作者：
Vugrin,D;WhitemoreJr,WJ;Batata,M
通讯作者：
Batata,M
播散性精原细胞瘤的化疗。
DOI：
--
发表时间：
1980
期刊：
Cancer clinical trials
影响因子：
--
作者：
Einhorn,LH;Williams,SD
通讯作者：
Williams,SD