Epidemiology of inapparent and symptomatic acute dengue virus infection: A prospective study of primary school children in Kamphaeng Phet, Thailand
Epidemiology of inapparent and symptomatic acute dengue virus infection: A prospective study of primary school children in Kamphaeng Phet, Thailand
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DOI：
10.1093/aje/kwf005
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发表时间：
2002-07-01
影响因子：
5
通讯作者：
Ennis, FA
中科院分区：
文献类型：
--
作者：
Endy, TP;Chunsuttiwat, S;Ennis, FA
登革热病毒是世界热带和亚热带地区发病的主要原因。关于隐性和严重登革病毒感染的流行病学和宿主决定因素的知识有限。在本文中，作者报告了在泰国北方的2,119名小学生队列中进行的登革热病毒传播和疾病严重程度的前瞻性研究的前3年的结果。1998年至2000年，共观察了717 106个人-学校日。1998年，隐性登革病毒感染和有症状登革病毒感染的发病率分别为4.3%和3.6%，1999年为3.2%和3.3%，2000年为1.4%和0.8%。1998年、1999年和2000年，症状性登革热病毒感染分别占急性病缺课人数的3.2%、7.1%和1.1%。急性登革病毒感染的早期症状复杂多变，难以与儿童发热性疾病的其他病因区分开来。作者的研究结果说明了登革热病毒感染的空间和时间多样性以及泰国学龄儿童登革热疾病的负担，他们的研究结果增加了对登革热病毒传播和疾病严重程度的理解，并提供了一种研究设计，以测试潜在的登革热疫苗的有效性。
Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Knowledge about the epidemiology and host determinants of inapparent and severe dengue virus infections is limited. In this paper, the authors report findings from the first 3 years of a prospective study of dengue virus transmission and disease severity conducted in a cohort of 2,119 elementary school children in northern Thailand. A total of 717,106 person-school days were observed from 1998 to 2000. The incidence of inapparent and of symptomatic dengue virus infection was 4.3% and 3.6% in 1998, 3.2% and 3.3% in 1999, and 1.4% and 0.8% in 2000, respectively. Symptomatic dengue virus infection was responsible for 3.2%, 7.1%, and 1.1% of acute-illness school absences in 1998, 1999, and 2000, respectively. The early symptom complex of acute dengue virus infection is protean and difficult to distinguish from other causes of febrile childhood illnesses. The authors' results illustrate the spatial and temporal diversity of dengue virus infection and the burden of dengue disease in schoolchildren in Thailand, Their findings increase understanding of dengue virus transmission and disease severity in a well-defined cohort population and offer a study design in which to test the efficacy of potential dengue vaccines.