Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis
Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis
复制标题
DOI：
10.1124/mol.65.1.99
复制
发表时间：
2004-01-01
影响因子：
3.6
通讯作者：
Yang, PC
中科院分区：
文献类型：
--
作者：
Chen, HW;Yu, SL;Yang, PC
姜黄素具有抗肿瘤侵袭和/或抗肿瘤转移的活性，但其作用机制尚不清楚。在这项研究中，基因表达谱的微阵列分析被用来表征姜黄素在高侵袭性肺腺癌细胞（CL 1 -5）中的抗侵袭机制。结果显示，姜黄素在远低于其细胞毒性水平（20 μ M）的浓度范围内显著降低CL 1 -5细胞的侵袭能力，并且这种抗侵袭作用是浓度依赖性的（0 μ M时为10.17+/-0.76x10（3）个细胞; 1 μ M时为5.67+/-1.53x10（3）个细胞; 5 μ M时为2.67+/-0.58x10（3）个细胞; 10 μ M时为1.15+/-1.03x10（3）个细胞; P
Curcumin has been reported to exhibit anti-invasive and/or antimetastatic activities, but the mechanism remains unclear. In this study, microarray analysis of gene expression profiles were used to characterize the anti-invasive mechanisms of curcumin in highly invasive lung adenocarcinoma cells (CL1-5). Results showed that curcumin significantly reduces the invasive capacity of CL1-5 cells in a concentration range far below its levels of cytotoxicity (20 muM) and that this anti-invasive effect was concentration dependent (10.17+/-0.76x10(3) cells at 0 muM; 5.67+/-1.53x10(3) cells at 1 muM; 2.67+/-0.58x10(3) cells at 5 muM; 1.15+/-1.03x10(3) cells at 10 muM; P