Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis
Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis
复制标题
耐多药结核病的病变异质性和长期异质性
DOI：
10.1093/infdis/jiab011
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发表时间：
2021-01-12
影响因子：
6.4
通讯作者：
Gao, Qian
中科院分区：
文献类型：
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作者：
Chen, Yiwang;Ji, Lecai;Gao, Qian
结核病的异质性耐药，即结核病患者体内只有一小部分细菌含有耐药突变，已经成为一个日益令人担忧的问题。然而，它的起源和流行仍然难以捉摸。本研究对31例耐多药肺结核患者的83株连续分离株进行了全基因组测序，21例患者(67.74%)的分离株检测到异源耐药。异抗性在宿主中持续很长时间，跨度从几个月到几年，并与多个结节病变有关。我们的研究结果表明，耐多药结核病患者中异药耐药现象普遍且持续存在，并可能影响其治疗方案的成功。
Tuberculosis heteroresistance, in which only a fraction of the bacteria in a patient with tuberculosis contains drug-resistant mutations, has been a rising concern. However, its origins and prevalence remain elusive. Here, whole-genome sequencing was performed on 83 serial isolates from 31 patients with multidrug-resistant tuberculosis, and heteroresistance was detected in isolates from 21 patients (67.74%). Heteroresistance persisted in the host for long periods, spanning months to years, and was associated with having multiple tubercular lesions. Our findings indicate that heteroresistance is common and persistent in patients with multidrug-resistant tuberculosis and may affect the success of their treatment regimens.