Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis
Trim21-mediated HIF-1α degradation attenuates aerobic glycolysis to inhibit renal cancer tumorigenesis and metastasis
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Trim21介导的HIF-1α降解减弱有氧糖酵解以抑制肾癌肿瘤发生和转移
DOI：
10.1016/j.canlet.2021.03.023
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发表时间：
2021-04-05
期刊：
影响因子：
9.7
通讯作者：
Bai, Jin
中科院分区：
文献类型：
--
作者：
Chen, Xintian;Li, Zhongwei;Bai, Jin
含三方基序的21（TRIM21）主要参与抗病毒反应和自身免疫性疾病。尽管据报道TRIM21在各种肿瘤中具有癌症或抗癌作用，但其在肾细胞癌（RCC）中的作用仍有待阐明。在这项研究中，我们证明了TRIM21在原代RCC组织中被下调。 RCC中的TRIM21低表达与临床病理学特征差和整体生存期短。此外，我们说明TRIM21通过泛素化介导的HIF-1α降解抑制RCC细胞糖酵解，这抑制了RCC细胞在体外和体内抑制RCC细胞的增殖，肿瘤发生，迁移和转移。我们的发现表明，TRIM21可能成为RCC患者预后的有希望的预测生物标志物。
Tripartite motif-containing 21 (Trim21) is mainly involved in antiviral responses and autoimmune diseases. Although Trim21 has been reported to have a cancer-promoting or anticancer effect in various tumours, its role in renal cell cancer (RCC) remains to be elucidated. In this study, we demonstrate that Trim21 is downregulated in primary RCC tissues. Low Trim21 expression in RCC is correlated with poor clinicopathological characteristics and short overall survival. Moreover, we illustrate that Trim21 inhibits RCC cells glycolysis through the ubiquitination-mediated degradation of HIF-1 alpha, which inhibits the proliferation, tumorigenesis, migration, and metastasis of RCC cells in vitro and in vivo. Our findings show that Trim21 may become a promising predictive biomarker for the prognosis of patients with RCC.