Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction
Helicobacter pylori-seropositivity along with pro-inflammatory interleukin-1 polymorphisms correlated with myocardial infarction
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幽门螺杆菌血清阳性以及促炎白细胞介素 1 多态性与心肌梗死相关
DOI：
10.1016/j.ctrsc.2016.03.002
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kazuko
中科院分区：
文献类型：
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作者：
Noriaki Tabata;Seiji Hokimoto*;Tomonori Akasaka;Daisuke Sueta;Yuichiro Arima;Kenji Sakamoto;Eiichiro Yamamoto;Yasuhiro Izumiya;Megumi Yamamuro;Kenichi Tsujita;Sunao Kojima;Koichi Kaikita;Kazunori Morita;Kentaro Oniki;Junji Saruwatari;Kazuko
背景白细胞介素1（IL-1）基因多态性的宿主遗传因素影响幽门螺杆菌感染的致病活性。我们检查了H。pylori感染的IL-1多态性患者与心肌梗死（MI）相关。材料和方法我们招募了594例连续的冠状动脉疾病患者，并排除了那些符合排除标准的患者。经年龄和性别匹配后，入选MI患者82例，对照组82例。Immunoglobulin G antibodies against H. pylori和IL-1多态性（IL-1 β-511碱基对和IL-1受体拮抗剂）进行了分析。我们使用EndoPAT 2000系统评估高敏C反应蛋白（hs-CRP）水平和反应性充血-外周动脉张力测定（RH-PAT）指数（RHI）。幽门螺杆菌血清学阳性率为45.1%，IL-1基因多态性为19.5%（P = 0.001）。IL-1基因多态性的pylori阳性患者血清hs-CRP自然对数水平显著高于对照组（分别为− 2.8 ± 1.0 vs. − 3.4 ± 0.6; P = 0.003和− 2.8 ± 0.9 vs. − 3.2 ± 0.6; P = 0.02），病例组和对照组RHI的自然对数水平显著降低（分别为0.51 ± 0.13 vs. 0.61 ± 0.23; P = 0.039和0.47 ± 0.13 vs. 0.69 ± 0.23; P = 0.005）。Logistic回归分析显示，IL-1基因多态性的幽门螺杆菌血清学阳性与MI显著相关（优势比4.83; 95%可信区间1.99-11.7; P < 0.001）。IL-1基因多态性的pylori阳性患者hs-CRP水平较高，RHI水平较低，且与MI显著相关。
BackgroundHost genetic factors of interleukin (IL)-1 polymorphisms influenceHelicobacter pyloriinfection pathogenic activity. We examined whetherH. pylori-infected patients with IL-1 polymorphisms are associated with myocardial infarction (MI).Materials and methodsWe recruited 594 consecutive coronary artery disease patients and excluded those who met exclusion criteria. After matching age and sex, 82 cases with MI and 82 controls were enrolled. Immunoglobulin G antibodies againstH. pyloriand IL-1 polymorphisms (IL-1 beta-511 base pairs and IL-1 receptor antagonist) were analyzed. We assessed high sensitivity C-reactive protein (hs-CRP) level and reactive hyperemia-peripheral arterial tonometry (RH-PAT) index (RHI) using the EndoPAT2000 system.ResultsThe simultaneous prevalence ofH. pylori-seropositivity and IL-1 polymorphisms was 45.1% and 19.5% in the cases and controls, respectively (P = 0.001).H. pylori-positive patients with IL-1 polymorphisms showed significantly higher serum levels of natural logarithm of hs-CRP in the cases and controls (− 2.8 ± 1.0 vs. − 3.4 ± 0.6, respectively; P = 0.003 and − 2.8 ± 0.9 vs. − 3.2 ± 0.6, respectively; P = 0.02) and significantly lower levels of natural logarithm of RHI in the cases and controls (0.51 ± 0.13 vs. 0.61 ± 0.23, respectively; P = 0.039 and 0.47 ± 0.13 vs. 0.69 ± 0.23, respectively; P = 0.005).H. pylori-seropositivity with IL-1 polymorphisms was significantly associated with MI by logistic regression analysis (odds ratio, 4.83; 95% confidence interval, 1.99–11.7; P < 0.001).ConclusionsH. pylori-positive patients with IL-1 polymorphisms showed higher levels of hs-CRP and lower levels of RHI, and were significantly correlated with the MI.