Identification of brain- and bone-specific breast cancer metastasis genes
Identification of brain- and bone-specific breast cancer metastasis genes
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DOI：
10.1016/j.canlet.2008.11.017
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发表时间：
2009-04-18
期刊：
影响因子：
9.7
通讯作者：
Seitz, Susanne
中科院分区：
文献类型：
--
作者：
Klein, Andreas;Olendrowitz, Christian;Seitz, Susanne
在乳腺癌中，转移灶分布相对广泛，最常见的部位是骨、区域淋巴结、肺、肝和脑。器官特异性转移的详细机制尚不清楚。在这项研究中，我们开始寻找与原发性人类乳腺癌脑转移或骨转移有关的基因。我们生成了源自原发性乳腺肿瘤的 18 个脑转移瘤和 8 个骨转移瘤的基因表达谱。我们鉴定了 73 个在脑转移和骨转移之间差异表达的基因。通过对应和聚类分析对差异基因表达谱进行可视化表明，转移灶清楚地分为两个不同的组，准确反映了其转移部位。此外，对复发至骨或脑的原发性乳腺肿瘤中的该基因组进行分析，可以根据肿瘤的转移部位对肿瘤进行准确的分类。所鉴定的基因可能被证明是预测乳腺癌患者转移部位的极好标记，并可能为个体患者提供量身定制的治疗。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
In breast cancer, metastases are relatively widely distributed, with the most common sites being bone, regional lymph nodes, lung, liver, and brain. The detailed mechanism of organ-specific metastasis is poorly understood. In this study, we initiated a search for genes that are implicated in brain or bone metastasis of primary human breast cancer. We generated gene expression profiles of 18 brain and eight bone metastases derived from primary breast tumors. We identified 73 genes differentially expressed between brain and bone metastases. Visualization of the differential gene expression profiles by correspondence and cluster analyses shows that the metastases clearly separate into two distinct groups as an exact reflection of their site of metastasis. Moreover, the analysis of this gene set in primary breast tumors relapsing to either bone or brain allowed accurate categorization of the tumors according to their metastatic site. The identified genes may prove to be excellent markers to predict the site of metastasis in breast cancer patients and could lead to tailor-made therapy to an individual patient. (C) 2008 Elsevier Ireland Ltd. All rights reserved.