COVID-19-Associated Hepatitis Complicating Recent Living Donor Liver Transplantation
COVID-19-Associated Hepatitis Complicating Recent Living Donor Liver Transplantation
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DOI：
10.5858/arpa.2020-0186-sa
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发表时间：
2020-08-01
影响因子：
4.6
通讯作者：
Lefkowitch, Jay H.
中科院分区：
文献类型：
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作者：
Lagana, Stephen M.;De Michele, Simona;Lefkowitch, Jay H.
我们报告了一例活体肝移植受者发生COVID-19肝炎的病例，其供体随后检测出COVID-19阳性。患者为患有胆道闭锁的女婴（加塞手术失败）。患者恢复良好，肝功能检查改善4天。术后第4天，患者出现呼吸窘迫和发热。COVID-19检测（聚合酶链反应）呈阳性。肝功能检查结果增加约5倍。肝活检显示中度急性肝炎，伴有明显的凋亡肝细胞簇和相关的细胞碎片。观察到小叶淋巴组织细胞性炎症。还观察到轻度至中度急性细胞排斥反应的典型门脉特征。
We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On postoperative day 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function test results increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted.