Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs.
Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs.
复制标题
血管压力对离体狗肺肺微脉管系统的影响。
DOI：
10.1152/jappl.1984.57.1.233
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Taylor,AE
中科院分区：
文献类型：
--
作者：
Rippe,B;Townsley,M;Thigpen,J;Parker,JC;Korthuis,RJ;Taylor,AE
已经在离体狗肺中研究了短期高肺血管压力对肺微循环过滤特性的影响。当左心房压力（Pla）小于30 cmH2O时，毛细血管滤过系数（Kf,c）与对照组（0.192 +/- 0.009 ml X min-1 X cmH2O–1 X 100 g-1）没有差异。在 23 次观察中的 17 次中，Pla 超过 55 cmH2O，Kf,c 至少是对照的 1.5 倍。在 13 个肺中的 10 个中，Kf,c 在 Pla 增加后 2 小时内恢复到控制值。然而，在其他三个实验中，Kf,c 没有返回到对照值。这些发现表明，肺微血管的过滤系数在高左心房压力（大于 55 cmH2O）下增加，可能代表现有毛孔的“拉伸”或一些大毛孔的打开。
The effects of short periods of high pulmonary vascular pressures on the filtration characteristics of the lung's microcirculation have been studied in isolated dog lungs. When left atrial pressures (Pla) were less than 30 cmH2O, the capillary filtration coefficient (Kf,c) was not different from that of controls (0.192 +/- 0.009 ml X min-1 X cmH2O–1 X 100 g-1). In 17 of 23 observations, where Pla exceeded 55 cmH2O, Kf,c was at least 1.5 times control. In 10 of 13 lungs, Kf,c returned to control values within 2 h after the Pla increase. However, in the other three experiments, Kf,c did not return to control values. These findings indicate that the filtration coefficient of pulmonary microvessels increases at high left atrial pressures (greater than 55 cmH2O) and may represent either a “stretching” of existing pores or opening of a few large pores.