Evidence for the adrenal source of androgens in precocious adrenarche.
Evidence for the adrenal source of androgens in precocious adrenarche.
复制标题
肾上腺初现早熟中雄激素的肾上腺来源的证据。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
D. Chow
中科院分区：
文献类型：
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作者：
S. Korth;L. Levine;M. New;D. Chow
为确定肾上腺性早熟的雄激素来源，对8例肾上腺早熟女童和5例肾上腺早熟儿童在肾上腺和性腺刺激和抑制条件下进行了血清雄激素测定。两组雄激素水平均随ACTH刺激而升高。肾上腺性早熟合并ACTH的女孩血清雄激素的刺激性比13名青春期前儿童更一致。人绒毛膜促性腺激素可使肾上腺早熟女童血清β4-雄烯二酮、睾酮和双氢睾酮升高，但对性早熟儿童无明显影响，表明HCG未能刺激肾上腺。地塞米松抑制降低了两组的所有雄激素水平，而去甲肾上腺素或Ovral则产生了不同的变化。这些研究支持肾上腺性早熟时雄激素的肾上腺来源，以及在这种情况下缺乏卵巢的贡献。
In order to determine the source of androgens in precocious adrenarche, serum androgens were determined in 8 girls with precocious adrenarche and 5 agonadal children in adrenarche under conditions of adrenal and gonadal stimulation and suppression. All androgens increased with ACTH stimulation in both groups. Stimulability of serum androgens in girls with precocious adrenarche with ACTH was more consistent than in 13 prepubertal children. Human chorionic gonadotrophin administration increased serum delta4-androstenedione, testosterone and dihydrotestosterone in the girls with precocious adrenarche but not in the agonadal children, demonstrating the failure of HCG to stimulate adrenals. Dexamethasone suppression decreased levels of all androgens in both groups, whereas Norlutin or Ovral produced variable changes. These studies support the adrenal origin of androgens in precocious adrenarche and the lack of ovarian contributions in this condition.