A genome-wide association study for milk production traits in Danish Jersey cattle using a 50K single nucleotide polymorphism chip
A genome-wide association study for milk production traits in Danish Jersey cattle using a 50K single nucleotide polymorphism chip
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DOI：
10.2527/jas.2009-2713
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Guldbrandtsen, B.
中科院分区：
文献类型：
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作者：
Mai, M. D.;Sahana, G.;Guldbrandtsen, B.
采用混合模型对丹麦泽西牛产奶性状的数量性状位点进行了全基因组关联分析。该分析纳入了1,039头公牛和33,090个SNP，并在27个BTA上检测到98个QTL和性状组合。其中乳指数QTL 30个，脂肪指数QTL 50个，蛋白质指数QTL 18个。证据显示，在14个BTA上存在33个全基因组QTL。其中7种对乳指数有影响，21种对脂肪指数有影响，5种对蛋白质指数有影响。其中，已有报道的全基因组QTL 26个，BTA4和BTA5为乳指数新QTL 2个，BTA4、BTA5、BTA13、BTA20和BTA29为脂肪指数新QTL 5个。我们发现了7个多效性或非常紧密连锁的QTL。大多数QTL与狭窄区域内的多态性相关，其中一些可能代表基因多态性的影响：DGAT1、酪蛋白、ARFGAP3、CYP11B1和cdc样激酶4。通过染色体宽阈值，检测到65个额外的QTL。其中许多可能代表QTL。从育种的角度来看，这一结果是有趣的，有助于寻找导致对产奶量性状重要的多态性的基因。
Quantitative trait loci for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index, and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, 7 had effects on milk index, 21 on fat index, and 5 on protein index. Among the genome-wide QTL, 26 have been previously reported, 2 on BTA4 and BTA5 were new for milk index, and 5 on BTA4, BTA5, BTA13, BTA20, and BTA29 were new QTL for fat index. We found 7 pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome-wide threshold, 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.