Functions of Circular RNAs Involved in Animal Skeletal Muscle Development – A Review
Functions of Circular RNAs Involved in Animal Skeletal Muscle Development – A Review
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DOI：
10.2478/aoas-2019-0053
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发表时间：
2020-01
影响因子：
1.9
通讯作者：
P. Adu-Asiamah;Q. Leng;H. Xu;J. Zheng;Zhihui Zhao;L. An;Li Zhang
中科院分区：
文献类型：
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作者：
P. Adu-Asiamah;Q. Leng;H. Xu;J. Zheng;Zhihui Zhao;L. An;Li Zhang
摘要在许多动物的骨骼肌中发现了环状RNA。它们的丰富性、多样性及其动态表达模式在骨骼肌的不同发育阶段和生理条件下已被揭示。近年来，研究发现circRNA广泛参与肌细胞的增殖和分化。它们还参与其他生命过程，例如充当microRNA（miRNA）海绵，剪接和转录的调节剂以及亲本基因表达的修饰剂，新出现的证据表明它们很有可能在几种细胞和组织中发挥重要作用，特别是肌肉。其他研究强调骨骼肌的生长和发育受蛋白质以及非编码RNA的调节，其中包括circRNA。因此，circRNA被认为是理解成肌细胞分子机制的重要生物调节因子。在这里，我们讨论了circRNA是如何在肌肉（成肌细胞）中大量表达的，以及它们在生长和发育中的关键作用。
Abstract Circular RNAs (circRNAs) have been identified in the skeletal muscle of numerous species of animals. Their abundance, diversity, and their dynamic expression patterns have been revealed in various developmental stages and physiological conditions in skeletal muscles. Recently, studies have made known that circRNAs widely participate in muscle cell proliferation and differentiation. They are also involved in other life processes such as functioning as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression with emerging pieces of evidence indicating a high chance of playing a vital role in several cells and tissues, especially the muscles. Other research has emphatically stated that the growth and development of skeletal muscle are regulated by proteins as well as non-coding RNAs, which involve circRNAs. Therefore, circRNAs have been considered significant biological regulators for understanding the molecular mechanisms of myoblasts. Here, we discuss how circRNAs are abundantly expressed in muscle (myoblast) and their critical roles in growth and development.