Dynamic changes in the tear film in dry eyes
Dynamic changes in the tear film in dry eyes
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DOI：
10.1167/iovs.05-0017
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发表时间：
2005-05-01
影响因子：
4.4
通讯作者：
Charman, WN
中科院分区：
文献类型：
--
作者：
Montés-Micó, R;Alió, JL;Charman, WN
目的。通过测量泪膜前表面的波前像差，观察干眼症患者泪膜的动态变化。对13例干眼症患者的7毫米瞳孔前表面像差进行了测定，测定时间间隔为1秒，眨眼后15秒。像差是根据角膜地形图提供的高程计算的。所有数据均采用泽尼克多项式进行分解。分别研究了总像差、球像差和共像差项。结果与正常眼相比较。结果测量包括与临床撕裂时间测量的比较。干眼症患者的总波前像差（RMS）在眨眼后至少为2.9 +/- 0.4秒，而正常患者的最小值为6.1 +/- 0.5秒。在两组中，最小的总像差似乎与相似像差的相似变化有关，而不是与球像差相关，球像差随时间单调增加。最小RMS畸变发生的时间与测量的泪液破裂时间有很好的相关性。通过测量泪膜前表面引入的光学像差的动态变化，对泪膜的变化有价值的认识，为干眼症的诊断提供了一种方便客观的方法。
PURPOSE. To examine the dynamics of the tear film in patients with dry eye by measuring the wavefront aberrations of the anterior surface of the film.METHODS. Anterior surface aberrations for a 7-mm pupil were determined in 13 patients with dry eye at 1-second time intervals, for 15 seconds after a blink. The aberrations were calculated from the elevations provided by corneal topography. All data were decomposed using Zernike polynomials. Total, spherical, and comalike aberrations terms were studied separately. Results were compared with those in normal eyes. Outcome measures included comparison with clinical tear breakup time measurements.RESULTS. The total root mean square ( RMS) wavefront aberration in patients with dry eye passed through in a minimum of 2.9 +/- 0.4 seconds after a blink in comparison to the minimum at 6.1 +/- 0.5 seconds in normal patients. In both groups, the minimum in total aberration appeared to be associated with similar changes in comalike aberrations, rather than in spherical aberrations, which increased monotonically with time. The time at which minimum RMS aberration occurred correlated reasonably well with the measured tear breakup times.CONCLUSIONS. Measurements of the dynamic changes in the optical aberrations introduced by the anterior tear film surface give valuable insights into tear film changes and may provide a convenient objective method for the diagnosis of dry eye.