Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury.
Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury.
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DOI：
10.1089/neu.2015.4012
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发表时间：
2016-05-01
影响因子：
4.2
通讯作者：
Asarnow RF
中科院分区：
文献类型：
--
作者：
Dennis EL;Hua X;Villalon-Reina J;Moran LM;Kernan C;Babikian T;Mink R;Babbitt C;Johnson J;Giza CC;Thompson PM;Asarnow RF
创伤性脑损伤（TBI）可导致广泛和长期的脑变性。TBI会在受伤后影响认知功能和大脑完整性多年，通常对大脑尚未发育成熟的儿童产生持久影响。虽然TBI对不同个体的影响不同，但基于张量的形态测量学（TBM）等图像分析方法可以在磁共振成像（MRI）上揭示脑萎缩的共同区域，初始损伤的继发性影响，这在受试者之间会有所不同。在这里，我们研究了36名急性期后（受伤后1-6个月）的儿童中度至重度TBI（msTBI）参与者和18名msTBI参与者，他们返回进行慢性评估，沿着，在两个时间点都有匹配良好的对照。参与者完成了一系列认知测试，我们用这些测试来创建一个全球认知表现评分。使用TBM，我们创建了区域脑容量的个体和组差异的三维（3D）地图。在急性和慢性时间点后，最大的组间差异是TBI组的侧脑室扩张和舌回减少。我们在扣带回、丘脑、梭状回以及整个额叶、颞叶和顶叶皮层发现了一些较小的体积减少集群。此外，我们发现我们的认知表现测量和区域脑容量之间存在广泛的关联。我们的研究结果表明，萎缩的模式仍然可以检测到1年后的损伤，这可能是部分的认知功能障碍经常发现的TBI。
Traumatic brain injury (TBI) can cause widespread and prolonged brain degeneration. TBI can affect cognitive function and brain integrity for many years after injury, often with lasting effects in children, whose brains are still immature. Although TBI varies in how it affects different individuals, image analysis methods such as tensor-based morphometry (TBM) can reveal common areas of brain atrophy on magnetic resonance imaging (MRI), secondary effects of the initial injury, which will differ between subjects. Here we studied 36 pediatric moderate to severe TBI (msTBI) participants in the post-acute phase (1–6 months post-injury) and 18 msTBI participants who returned for their chronic assessment, along with well-matched controls at both time-points. Participants completed a battery of cognitive tests that we used to create a global cognitive performance score. Using TBM, we created three-dimensional (3D) maps of individual and group differences in regional brain volumes. At both the post-acute and chronic time-points, the greatest group differences were expansion of the lateral ventricles and reduction of the lingual gyrus in the TBI group. We found a number of smaller clusters of volume reduction in the cingulate gyrus, thalamus, and fusiform gyrus, and throughout the frontal, temporal, and parietal cortices. Additionally, we found extensive associations between our cognitive performance measure and regional brain volume. Our results indicate a pattern of atrophy still detectable 1-year post-injury, which may partially underlie the cognitive deficits frequently found in TBI.