Biomarkers of ovulation, endometrial receptivity, fertilisation, implantation and early pregnancy progression
Biomarkers of ovulation, endometrial receptivity, fertilisation, implantation and early pregnancy progression
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DOI：
10.1111/j.1365-3016.2006.00766.x
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发表时间：
2006-11-01
影响因子：
2.8
通讯作者：
Rockett, John C.
中科院分区：
文献类型：
--
作者：
Campbell, Kenneth L.;Rockett, John C.
对早期孕前和孕产期暴露和人类发育结果的兴趣日益增加，导致了从受孕前到妊娠、出生和童年监测受试者的研究。监测排卵、子宫内膜容受性、受精、着床和妊娠需要无创收集生物信息和样本，并测量与上述生理事件相关的生化和生物标志物（生物标志物）。本文介绍了流行病学研究中需要的生物标志物的一些关键特征，鉴定了一些现有的和潜在的生物标志物和可用的测量设备，并提出了鉴定和开发新的生物标志物的一些方向，这些生物标志物可能用于女性生殖功能和胚胎发育的纵向研究。
Increasing interest in early preconception and periconception exposures and human developmental outcomes has led to studies that monitor subjects from before conception to gestation, birth and childhood. Monitoring ovulation, endometrial receptivity, fertilisation, implantation and gestation requires the non-invasive collection of biological information and samples, and the measurement of biochemical and biological markers (biomarkers) that are associated with the aforementioned physiological events. This paper describes some of the key features of biomarkers needed for epidemiological studies, identifies some existing and potential biomarkers and available measurement devices, and suggests some directions for identification and development of new biomarkers that might be employed in longitudinal studies involving the analysis of female reproductive function and of embryonic development.