Long non-coding RNA FENDRR inhibits cell proliferation and is associated with good prognosis in breast cancer.
Long non-coding RNA FENDRR inhibits cell proliferation and is associated with good prognosis in breast cancer.
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长链非编码 RNA FENDRR 抑制细胞增殖并与乳腺癌的良好预后相关
DOI：
10.2147/ott.s149511
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发表时间：
2018
影响因子：
4
通讯作者：
Guan X
中科院分区：
文献类型：
--
作者：
Li Y;Zhang W;Liu P;Xu Y;Tang L;Chen W;Guan X
Introduction FENDRR is a long non-coding RNA (lncRNA) that mediates the modification of the epigenetic landscape of target promoters by binding to polycomb repressive complex 2. However, the role of FENDRR in breast cancer remains unknown. Materials and methods We detected the expression of FENDRR in 52 breast cancer patients’ tissues and five breast cancer cell lines. The association between FENDRR expression and clinicopathological features and prognosis of breast cancer patients was also analyzed. Moreover, cell proliferation assays, flow cytometry analysis, wound-healing assays, and transwell migration assays were performed to detect the biological effects of FENDRR in the breast cancer cells. A xenograft model was used to explore the role of FENDRR expression on tumor growth. Results We found that FENDRR expression was lower in breast cancer cell lines and cancerous tissues than in the adjacent normal tissues. Low expression of FENDRR was associated with a shorter overall survival and a shorter progression-free survival in breast cancer patients (p<0.001, p<0.001, respectively). We found that FENDRR inhibits breast cancer cell proliferation and migration and promotes cell apoptosis, while FENDRR knockdown promotes breast cancer cell proliferation and migration and suppresses cell apoptosis. Finally, we also detected that FENDRR overexpression could inhibit tumor growth in a xenograft model. Conclusion Our data suggested that FENDRR inhibits breast cancer cell proliferation, promotes cell apoptosis, and is associated with good prognosis in breast cancer. Thus, FENDRR plays an important role in the growth and progression of breast cancer.
