Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time
Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time
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DOI：
10.1016/0264-410x(96)00061-8
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发表时间：
1996-08-01
期刊：
影响因子：
5.5
通讯作者：
VanHoecke, C
中科院分区：
文献类型：
--
作者：
Kunzel, W;Glathe, H;VanHoecke, C
我们研究了42名健康志愿者（40+/-13岁）首次接种三价灭活裂解流感疫苗后或前一年接种疫苗后免疫应答的差异。在40周内连续收集血清样品。先前接种疫苗的志愿者在接种前血清中显示出40-92%的保护性抗体水平。第一次接种疫苗的受试者比以前接种疫苗的受试者有更高的应答率和平均抗体增加倍数。两组在接种后7天的保护性抗体滴度均为59%，70%的接种者在280天后仍保持保护性抗体滴度。这些结果证实了早期关于快速免疫反应的发现，并可能对未来的疫苗接种政策产生影响。版权所有（C）1996 Elsevier Science Ltd.
We studied differences in immune responses after first time immunization with a trivalent inactivated split influenza vaccine, or after vaccination in the preceding year, in 42 healthy volunteers (40+/-13 years). Sequential serum samples were collected over 40 weeks. Previously vaccinated volunteers exhibited 40-92% protective antibody levels in their prevaccination sera. Subjects vaccinated for the first time had higher response rates and meanfold antibody increases than those vaccinated previously. Both groups had protective antibody titres 59% 7 days after vaccination and 70% of vaccinees maintained protective antibody titres after 280 days. The results corroborate earlier findings on the rapid immune response and may have a bearing on future vaccination policy. Copyright (C) 1996 Elsevier Science Ltd.