The Role of Macrophages in Staphylococcus aureus Infection.
The Role of Macrophages in Staphylococcus aureus Infection.
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DOI：
10.3389/fimmu.2020.620339
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发表时间：
2020
影响因子：
7.3
通讯作者：
Foster SJ
中科院分区：
文献类型：
--
作者：
Pidwill GR;Gibson JF;Cole J;Renshaw SA;Foster SJ
金黄色葡萄球菌是人类共生菌群的一员，存在于宿主的多个部位，显然是良性的。然而，作为一种机会主义病原体，它也能引起一系列严重疾病。这需要一种绕过先天免疫系统建立感染的能力。专业吞噬细胞，主要是巨噬细胞和中性粒细胞，是与金黄色葡萄球菌相互作用的关键先天免疫细胞，扮演着控制和解决感染的守门人的角色。最近的研究强调了巨噬细胞在金黄色葡萄球菌感染中的重要作用，使用了广泛的杀伤机制。在防御方面，金黄色葡萄球菌已经进化出多种策略来在巨噬细胞中生存、操纵和逃脱，使它们不仅可以破坏，还可以利用我们免疫系统的这一关键元素。Macrophage-S。金黄色葡萄球菌相互作用是多方面的，在感染结果中有直接作用。深入了解这些宿主-病原体相互作用可能有助于未来的治疗发展。这篇综述研究了巨噬细胞与金黄色葡萄球菌在感染的所有阶段的相互作用，特别强调了决定感染结果的机制。
Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome.
影响因子：
4.3
作者：
Massilamany, Chandirasegaran;Gangaplara, Arunakumar;Gardner, Donald J.;Musser, James M.;Steffen, David;Somerville, Greg A.;Reddy, Jay
通讯作者：
Reddy, Jay