Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study.
Sleep duration and plasma leptin concentrations in early pregnancy among lean and overweight/obese women: a cross sectional study.
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DOI：
10.1186/1756-0500-7-20
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发表时间：
2014-01-09
影响因子：
1.8
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Qiu C;Frederick IO;Sorensen TK;Enquobahrie DA;Williams MA
妊娠早期睡眠时间短预示着妊娠期糖尿病和先兆子痫；这些关联的机制尚不清楚。瘦素是一种脂肪细胞衍生的多肽，参与调节食物摄入和能量消耗，可能在这些观察到的联系中发挥作用。考虑到将短睡眠时间与瘦素联系起来的报道不一致，以及在孕妇中缺乏研究，我们检查了孕妇睡眠时间与怀孕早期血浆瘦素的关系。这项横断面研究包括830名孕妇。测定妊娠13周左右孕妇的血浆瘦素水平。睡眠时间分类为：≤5、6、7-8(参考)和≥9小时。不同类别的瘦素浓度的差异使用线性回归来估计。完成了对苗条和超重/肥胖女性的分析。总体而言，睡眠时间长的女性血浆瘦素水平升高(p值= 0.04)。然而，在睡眠时间较短的女性中，瘦素浓度并没有统计上的显著升高。瘦素与瘦身女性的睡眠时间没有关联。在超重/肥胖女性中，观察到瘦素与睡眠时间之间的U型关系：与对照组相比，报告β= 5小时睡眠的女性的平均瘦素水平升高(β= 21.96 ng/ml，P<； 0.001)；报告≥9小时睡眠的女性的瘦素水平也升高(β= 4.29 ng/ml，P= 0.09)。在超重/肥胖女性中，睡眠时间短和睡眠时间长与瘦素升高有关。这些数据增加了一些证据，有助于理解睡眠时间与妊娠并发症的机制关系。
Early-pregnancy short sleep duration is predictive of gestational diabetes and preeclampsia; mechanisms for these associations are unknown. Leptin, an adipocyte-derived peptide involved in regulating food intake and energy expenditure, may play a role in these observed associations. Given inconsistent reports linking short sleep duration with leptin, and absence of studies among pregnant women, we examined the association of maternal sleep duration with plasma leptin in early pregnancy. This cross-sectional study included 830 pregnant women. Plasma leptin was measured in samples collected around 13 weeks gestation. Sleep duration was categorized as: ≤5, 6, 7–8 (reference), and ≥9 hours. Differences in leptin concentrations across categories were estimated using linear regression. Analyses were completed for lean and overweight/obese women. Overall, women with long sleep duration had elevated plasma leptin (p-value = 0.04). However, leptin concentrations were not statistically significantly elevated in women with a short sleep duration. There was no association of leptin with sleep duration among lean women. Among overweight/obese women, a U-shaped relation between leptin and sleep duration was observed: Mean leptin was elevated (β = 21.96 ng/ml, P < 0.001) among women reporting ≤5 hour of sleep compared with reference group; and women reporting ≥9 hours of sleep also had elevated leptin (β = 4.29 ng/ml, P = 0.09). Short sleep duration, and to a lesser extent long sleep duration, were associated with elevated leptin among overweight/obese women. These data add some evidence to help understand mechanistic relationships of sleep duration with pregnancy complications.