Event-related fMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia
Event-related fMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia
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DOI：
10.1037/0021-843x.112.4.689
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发表时间：
2003-11-01
影响因子：
4.6
通讯作者：
Carter, CS
中科院分区：
文献类型：
--
作者：
MacDonald, AW;Carter, CS
上下文处理被概念化为一种执行功能，涉及自愿的、复杂的行动，如克服自动反应。本研究验证了精神分裂症患者的上下文加工缺陷与左背外侧前额叶皮层（DLPFC）功能障碍有关的假设。使用事件相关功能磁共振成像（fMRI），17名对照组和17名服药组患者进行了AX任务的一个版本，其中学习，自动反应必须被抑制。在对照组中，当准备克服自动反应时，左DLPFC活性增加，而精神分裂症患者没有表现出差异激活。在对照组中，上下文处理似乎与线索的差异表征有关，线索的差异表征与克服自动反应提供自上而下支持的需要有关。这种机制似乎在精神分裂症患者中受损。
Context processing is conceptualized as an executive function involved in voluntary, complex actions such as overcoming automatic responses. The present study tested the hypothesis that context-processing deficits in patients with schizophrenia are associated with a dysfunction of left dorsolateral prefrontal cortex (DLPFC). Using event-related functional magnetic resonance imaging (fMRI), 17 controls and 17 medicated patients performed a version of the AX task in which a learned, automatic response had to be inhibited. In controls, left DLPFC activity increased when preparing to overcome an automatic response, whereas patients with schizophrenia showed no differential activation. In controls, context processing appeared to be associated with the differential representation Of Cues associated with the need to provide top-down support for overcoming automatic responses. This mechanism appeared to be impaired in patients with schizophrenia.