Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles
Engineered Polypeptides as a Tool for Controlling Catalytic Active Janus Particles
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DOI：
10.1021/acsaenm.3c00263
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发表时间：
2023-08
期刊：
影响因子：
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通讯作者：
Marola W. Issa;Diego Calderon;Olivia Kamlet;S. Asaei;J. Renner;C. Wirth
中科院分区：
文献类型：
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作者：
Marola W. Issa;Diego Calderon;Olivia Kamlet;S. Asaei;J. Renner;C. Wirth
活性Janus胶体是结合了联合收割机两种不同化学或物理表面性质的功能性颗粒。这类片状粒子的各向异性性质使它们能够收集和重定向能量，以产生导致自主运动的局部力。调节Janus粒子表面所经历的表面力或表面的响应性提供了进一步控制的途径。在社区中有广泛的努力，以促进对主动系统的基本理解和设计这种控制。本文综述了近年来在催化活性Janus胶体、肽和多肽工程和设计方面的工作，并介绍了工程多肽如何用于控制催化活性粒子的运动。本文综述了在低分子量聚乙二醇（PEG）存在下5 μm催化Janus球的主动运动的非特异性效应实验。先前的工作已经发现，在无限稀释的颗粒浓度下，在溶液中添加PEG降低了颗粒推进速度。进一步增加颗粒浓度导致聚簇在低浓度的PEG，但聚簇，然后减少在高浓度的PEG。这些结果启发了本文中提出的3 μm颗粒的工作，其显示特异性附着于铂帽的铂结合肽降低了推进速度。这些数据支持使用工程肽作为控制催化活性Janus颗粒活性的工具的途径。总体而言，本文强调了如何非特异性和特异性分子相互作用可以实现主动系统的控制。
Active Janus colloids are functional particles that combine two distinct chemical or physical surface properties. The anisotropic nature of this class of patchy particles allows them to harvest and redirect energy to create a local force that leads to autonomous motion. Modulating the surface forces experienced by or the responsiveness of a Janus particle’s surface offer an avenue of further control. There are broad efforts in the community to advance the fundamental understanding of and engineer such control into active systems. This article aims to summarize recent work in catalytic active Janus colloids, peptide and polypeptide engineering and design, and present work showing how engineered polypeptides can be used to control motion of catalytic active particles. Experiments probing nonspecific effects are reviewed that measured the active motion of 5 μm catalytic Janus spheres in the presence of low molecular weight polyethylene glycol (PEG). Previous work has found that at infinitely dilute concentrations of particles, the addition of PEG in solution reduced particle propulsion speed. Further increasing particle concentration led to increased clustering at low concentrations of PEG, but clustering was then reduced at high concentrations of PEG. These results inspired work presented herein with 3 μm particles that shows platinum binding peptides that specifically attach to the platinum cap reduced the propulsion speed. These data support a pathway for using engineered peptides as tools for controlling the activity of catalytic active Janus particles. Overall, this article highlights how nonspecific and specific molecular interactions can achieve control in active systems.