Hematopoietic cell regulation of osteoblast proliferation and differentiation.
Hematopoietic cell regulation of osteoblast proliferation and differentiation.
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DOI：
10.1007/s11914-011-0048-1
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发表时间：
2011-06
影响因子：
4.3
通讯作者：
Kacena, Melissa A
中科院分区：
文献类型：
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作者：
Bethel, Monique;Srour, Edward F;Kacena, Melissa A
过去几十年来，已经揭示了造血谱系细胞与间充质谱系的成骨细胞（OB）之间的许多相互作用。例如，OB是造血干细胞（HSC）生态位中的重要参与者，并且已知OB影响破骨细胞（OC）发育。因此，尽管关于OB对造血细胞的影响已经知道很多，但关于造血细胞对OB的影响知之甚少。在这里，我们将回顾这种相互关系：造血细胞对OB的影响。具体来说，我们将研究造血细胞如HSC、淋巴细胞和巨核细胞以及造血细胞来源的OC对OB增殖、分化和功能
The last several decades have revealed numerous interactions between cells of the hematopoietic lineage and osteoblasts (OBs) of the mesenchymal lineage. For example, OBs are important players in the hematopoietic stem cell (HSC) niche and OBs are known to impact osteoclast (OC) development. Thus, although much is known regarding the impact OBs have on hematopoietic cells, less is known about the impact of hematopoietic cells on OBs. Here we will review this reciprocal relationship: the effects of hematopoietic cells on OBs. Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell–derived OCs on OB proliferation, differentiation, and function.