Intracortically distributed neurovascular coupling relationships within and between human somatosensory cortices
Intracortically distributed neurovascular coupling relationships within and between human somatosensory cortices
复制标题
DOI：
10.1093/cercor/bhk014
复制
发表时间：
2007-03-01
期刊：
影响因子：
3.7
通讯作者：
Boniface, S. J.
中科院分区：
文献类型：
--
作者：
Arthurs, O. J.;Donovan, T.;Boniface, S. J.
神经元细胞活动与其血液供应的耦合对于人脑的生理学是至关重要的，并且已经讨论了超过世纪。在一些动物研究中已经证明了这种关系的线性，但在人类中缺乏证据。在这项研究中，我们比较了头皮诱发电位和功能性磁共振成像（fMRI）血氧水平依赖（BOLD）的信号从健康的人类志愿者与体感刺激的强度变化。通过根据相应强度的诱发电位振幅对fMRI图像进行加权，我们测试了这2个数据集之间的正相关和负相关以及线性程度。初级躯体感觉皮层的血流动力学变化与神经元活动呈显著线性正相关，二次贡献较小。同时，其他皮质区对应的nonstimulated四肢被发现协变负和线性的半球同侧和对侧的刺激。这些并发和双边的皮质动力学，以及区域内的特点，这种神经血管耦合，都比迄今为止被认为是更复杂的，具有相当大的影响。
The coupling of neuronal cellular activity to its blood supply is of critical importance to the physiology of the human brain and has been under discussion for more than a century. Linearity in this relationship has been demonstrated in some animal studies, but evidence is lacking in humans. In this study, we compared scalp evoked potentials and the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal from healthy human volunteers with changes in the intensity of a somatosensory stimulus. By weighting the fMRI images according to the evoked potential amplitude at corresponding intensities, we tested for positive and negative covariation between these 2 data sets and the extent to which these were linear. Hemodynamic changes in primary somatosensory cortex covaried positively with neuronal activity in a predominantly linear manner, with a small quadratic contribution. Simultaneously, other cortical areas corresponding to the nonstimulated limbs were found to covary negatively and linearly in the hemispheres ipsilateral and contralateral to the stimulus. These concurrent and bilateral cortical dynamics, as well as the intraregional features of this neurovascular coupling, are both more complex than had been considered to date, with considerable implications.