A voxel-based morphometric study of ageing in 465 normal adult human brains
A voxel-based morphometric study of ageing in 465 normal adult human brains
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DOI：
10.1006/nimg.2001.0786
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发表时间：
2001-07-01
期刊：
影响因子：
5.7
通讯作者：
Frackowiak, RSJ
中科院分区：
文献类型：
--
作者：
Good, CD;Johnsrude, IS;Frackowiak, RSJ
基于体素的形态测量（VBM）是一种全脑、无偏的技术，用于表征结构磁共振图像中的区域脑体积和组织浓度差异。我们描述了一种优化的VBM方法来检查年龄对465名正常成年人灰质、白质和脑脊液的影响。全球灰质体积随着年龄的增长呈线性下降，男性的下降幅度更大。双侧脑岛、顶叶上回、中央脑沟和扣带脑沟均出现局部加速丧失。杏仁核、海马体和内嗅皮层显示出很少或没有年龄影响（相对保存）的区域。脑白质不随年龄的增长而下降，但局部区域的损失和保存速度相对加快。没有年龄和性别的相互作用对区域特定的影响。这些结果证实了先前的报道，并表明VBM是研究人类衰老过程中大脑结构相关的一种有用的技术。(C) 2001学术出版社。
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans. (C) 2001 Academic Press.