Exploring and exploiting chemistry at the cell surface
Exploring and exploiting chemistry at the cell surface
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DOI：
10.1038/nchem.1090
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发表时间：
2011-08-01
期刊：
影响因子：
21.8
通讯作者：
Stevens, Molly M.
中科院分区：
文献类型：
--
作者：
Mager, Morgan D.;LaPointe, Vanessa;Stevens, Molly M.
设计材料的表面化学，使其能够与细胞接触是一项非常艰巨的任务。细胞表面由数千种不同的脂质、蛋白质和碳水化合物组成，它们在三维空间中以多种长度尺度错综复杂地（动态地）排列。这种复杂性对研究生物活性界面的化学家来说既是挑战也是机遇。在这里，我们将讨论如何通过跨学科材料合成来应对这些挑战。我们还审查了最流行的类功能分子接枝在工程表面，并探讨一些替代品，可能提供更大的灵活性和特异性。最后，我们讨论了新兴领域的动态表面能够刺激和响应细胞活动在真实的时间。
Engineering the surface chemistry of a material so that it can interface with cells is an extraordinarily demanding task. The surface of a cell is composed of thousands of different lipids, proteins and carbohydrates, all intricately ( and dynamically) arranged in three dimensions on multiple length scales. This complexity presents both a challenge and an opportunity to chemists working on bioactive interfaces. Here we discuss how some of these challenges can be met with interdisciplinary material synthesis. We also review the most popular classes of functional molecules grafted on engineered surfaces and explore some alternatives that may offer greater flexibility and specificity. Finally, we discuss the emerging field of dynamic surfaces capable of stimulating and responding to cellular activity in real time.