Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity.

Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity.
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DOI:
10.4161/cam.22408
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发表时间:
2012-11
影响因子:
3.2
通讯作者:
Mackenzie F
Mackenzie F
中科院分区:
生物学3区
文献类型:
--
作者:
Tillo M;Ruhrberg C;Mackenzie F

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突触的形成、维持和可塑性对于神经系统及其靶器官的正确功能至关重要。在发育过程中,这些过程能够建立适当的神经回路。在成年期,它们可以适应生理和环境的变化。在这篇综述中,我们讨论了两个经典轴突和血管引导信号家族在突触发生和突触可塑性中的新作用,即信号蛋白和血管内皮生长因子(VEGF)。它们对突触形成和功能的贡献为这些分子在发育、成年和疾病中的重叠和互补作用谱添加了新的方面。
Synapse formation, maintenance and plasticity are critical for the correct function of the nervous system and its target organs. During development, these processes enable the establishment of appropriate neural circuits. During adulthood, they allow adaptation to both physiological and environmental changes. In this review, we discuss emerging roles for two families of classical axon and vascular guidance cues in synaptogenesis and synaptic plasticity, the semaphorins and the vascular endothelial growth factors (VEGFs). Their contribution to synapse formation and function add a new facet to the spectrum of overlapping and complementary roles for these molecules in development, adulthood and disease.
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