Toll-like receptor 7 and Toll-like receptor 9 agonists effectively enhance immunological memory in Plasmodium chabaudi infected BALB/c mice
Toll-like receptor 7 and Toll-like receptor 9 agonists effectively enhance immunological memory in Plasmodium chabaudi infected BALB/c mice
复制标题
Toll样受体7和Toll样受体9激动剂有效增强查鲍迪疟原虫感染的BALB/c小鼠的免疫记忆
DOI：
10.1016/j.intimp.2020.106248
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发表时间：
2020
影响因子：
5.6
通讯作者：
Cao Yaming
中科院分区：
文献类型：
--
作者：
Gao Wenyan;Sun Xiaodan;Li Danni;Sun Lin;He Yang;Wei Huanping;Jin Feng;Cao Yaming
疟疾是人类历史上最具破坏性的疾病之一。在许多发展中国家，疟疾仍然是一个重大的健康负担，每年约有一百万人死亡，其中大多数是五岁以下的儿童[1]。血液阶段感染导致宿主免疫系统产生促炎和抗炎介质[2]。慢性疟疾感染通常会促进免疫记忆形成[3]，激活的免疫记忆细胞会迅速产生高亲和力抗体以防止再次感染[4]。研究表明，抗体依赖性机制对于慢性期感染的彻底解决非常重要[4]。针对慢性疟疾感染的保护性免疫特别复杂，取决于长寿命浆细胞 (LLPC) 和记忆 B 细胞 (MBC) 的生成[5]。一些T细胞还参与免疫记忆形成过程[6]，其中中央记忆T细胞（Tcm）和效应记忆T细胞（Tem）构成两个亚群[7]。当再次感染疟原虫时，Tcm和Tem迅速进入细胞周期，合成细胞因子，并分化为细胞毒性淋巴细胞[8]。滤泡辅助 T 细胞 (Tfh) 也被证明在产生长效抗体反应中发挥着关键作用 [9]。
Malaria is one of the most devastating diseases of human history. In many developing countries, malaria remains a significant health burden with around one million deaths per year, mostly in children under the age of five [1]. Blood stage infections lead to production of both pro-inflammatory and anti-inflammatory mediators by the host immune system [2]. Chronic malaria infections usually promote immunological memory formation [3], and activated immunological memory cells rapidly produce high-affinity antibodies to protect against re-infections [4].It has been shown that antibody dependent mechanisms are important for complete resolution of infections during the chronic phase [4]. Protective immunity against chronic malaria infection is particularly complex, and depends on the generation of long-lived plasma cells (LLPCs) and memory B cells (MBC)[5]. Some T cells are also involved in the process of immunological memory formation [6], with central memory T cells (Tcm) and effector memory T cells (Tem) constituting two subpopulations [7]. When re-infected with Plasmodium, Tcm and Tem rapidly enter the cell cycle, synthesize cytokines, and differentiate into cytotoxic lymphocytes [8]. Follicular helper T cells (Tfh) have also been shown to play a critical role in generating long-lived antibody responses [9].